Endocrine Abstracts

Circadian mechanisms regulate metabolism in adipose tissues. The genes encoding the circadian regulatory proteins oscillate over a 24 h period in human and murine adipose tissue depots,. This expression profile is entrained by photic stimuli, temporally restricted food access, and/or nuclear hormone receptor ligands, such as glucocorticoids. In mice, deletion or mutation of the circadian regulatory genes, clock and PPAR gamma coactivator 1 (PGC1), is associated with increased ...